Which hormone is commonly involved in weight regulation in eating disorders?

Leptin is a hormone that plays a crucial role in regulating energy balance and body weight. It is produced by adipose (fat) tissue and serves as a signal to the brain regarding the body’s energy status. When fat stores increase, leptin levels rise, which typically signals the body to increase energy expenditure and reduce appetite. Conversely, when fat stores decrease, leptin levels fall, signaling the body to conserve energy and increase hunger.

In the context of eating disorders, such as anorexia nervosa or bulimia nervosa, the regulation of leptin can become disrupted. Individuals with eating disorders often have reduced body fat, which leads to lower leptin levels. This can perpetuate a cycle of hunger and fat loss, complicating the management of their condition. On the other hand, abnormal levels of leptin may also affect mood and behavior, further contributing to disordered eating patterns.

The other hormones mentioned, such as insulin, ghrelin, and cortisol, also have roles in metabolism and appetite regulation, but leptin is most directly linked to weight regulation in the context of eating disorders, particularly due to its relationship with body fat and energy homeostasis.