What symptom is commonly associated with pancreatic adenocarcinoma?

Jaundice is a common symptom associated with pancreatic adenocarcinoma due to the tumor's location and its impact on surrounding structures. The pancreas is situated adjacent to the bile duct, and when a tumor grows in the pancreas, it can obstruct the bile duct. This obstruction leads to a buildup of bilirubin in the bloodstream, resulting in jaundice, which is characterized by yellowing of the skin and eyes, dark urine, and pale stools.

In addition to jaundice, other symptoms of pancreatic cancer may include abdominal pain, weight loss, and changes in appetite, but jaundice stands out as a significant clinical sign due to its direct correlation with bile duct obstruction. The other options listed, such as chest pain, shortness of breath, and severe headache, are not typically associated with pancreatic adenocarcinoma and would suggest different underlying issues or conditions.