What is one of the potential effects of high doses of niacin?

High doses of niacin, also known as vitamin B3, can lead to liver toxicity. Niacin is generally safe at recommended doses; however, when taken in high amounts, it can increase the risk of hepatotoxicity. This is especially relevant for formulations such as sustained-release niacin, which can exert a greater harmful effect on the liver.

Liver toxicity from high doses may manifest as elevated liver enzymes and, in severe cases, can progress to more serious liver damage. Monitoring liver function is therefore crucial for individuals taking high doses of niacin, particularly when used for conditions such as dyslipidemia.

The other effects listed, while potentially concerning with other substances or conditions, are not typically associated with excessive niacin consumption. For instance, hypoglycemia is more related to medications that lower blood sugar rather than niacin. Kidney damage is not widely recognized as a common adverse effect of niacin, and heart failure is not a direct consequence of high niacin dosage either.