What condition is often associated with a high level of PSA?

A high level of prostate-specific antigen (PSA) is most commonly associated with prostate cancer. PSA is a protein produced by both normal and malignant cells of the prostate gland, and its levels can increase in the presence of prostate cancer due to the uncontrolled growth of cancerous cells. Elevated PSA levels may indicate the development or progression of prostate cancer, making this condition a primary concern when high PSA levels are detected in a patient.

While benign prostatic hyperplasia (BPH) can also lead to elevated PSA levels, the context of the question is focused on the condition most specifically linked to significantly high PSA levels, which is commonly understood to be prostate cancer. Other conditions like asthma and chronic bronchitis do not have any direct correlation with PSA levels, as they pertain to respiratory issues rather than conditions affecting the prostate. Therefore, prostate cancer stands out as the key association when considering high PSA levels.