The presence of eosinophils is primarily associated with which immunoglobulin?

The presence of eosinophils is primarily associated with immunoglobulin E (IgE). Eosinophils are a type of white blood cell that plays a crucial role in the immune response, particularly in the context of allergies and parasitic infections. When allergens or parasites enter the body, IgE antibodies bind to their antigens. This binding results in the activation of eosinophils, leading to their accumulation at sites of inflammation.

IgE is known for its role in hypersensitivity reactions, such as asthma and allergic rhinitis. The interaction between IgE and eosinophils is a key component of the type I hypersensitivity reaction, which is mediated by the release of histamines and other inflammatory mediators from mast cells and basophils. This process can subsequently lead to the recruitment of eosinophils to the affected areas, magnifying the inflammatory response.

The other immunoglobulins—IgG, IgA, and IgM—serve various functions in the immune system, but they do not have the same direct correlation with eosinophil activation and function as IgE does. For instance, IgG is the most abundant antibody in circulation and is important in the immune response to infections, while IgA is