How is infectious mononucleosis most often transmitted?

Infectious mononucleosis, often referred to as "mono," is primarily transmitted through body fluids, with saliva being the main vector. This transmission occurs commonly through activities such as kissing, sharing drinks or utensils, and other close contact behaviors where saliva might be exchanged. The Epstein-Barr virus (EBV), which causes infectious mononucleosis, has a high prevalence in the saliva of infected individuals, making it a focal point for transmission.

Other modes of transmission, such as airborne droplets, blood transfusion, and contaminated food, are not significant routes for the spread of infectious mononucleosis. Airborne transmission is more commonly associated with respiratory infections, whereas blood transfusion-related transmission is rare for EBV. Contaminated food is not a recognized transmission route for this virus either. Thus, understanding the primary role of saliva in the transmission of infectious mononucleosis is crucial, as it highlights the importance of personal contact in the spread of this condition.